Ceftriaxone concentration dependent
2019年7月5日 — Peak:MIC is the parameter to optimize for concentration-dependent antibiotics. Time>MIC is the parameter to ... Ceftriaxone, Klebsiella sp. ,AUC/MIC [area under the inhibitory time curve (AUIC)] was chosen as the pharmacodynamic parameter for this analysis since ceftriaxone is a time-dependent killer and high peak concentrations are not needed.
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 Ceftriaxone concentration dependent 相關參考資料
Antimicrobial Dosing and Kill Characteristics • LITFL • CCC ID
2019年4月5日 — use a 12-hourly dosing regimen; i.e. ceftriaxone 1 g [child: 25 mg/kg up to ... Cmax = maximal or peak concentration; “concentration-dependent ... https://litfl.com Clinical Pharmacology of Antibiotics | American Society of ...
2019年7月5日 — Peak:MIC is the parameter to optimize for concentration-dependent antibiotics. Time>MIC is the parameter to ... Ceftriaxone, Klebsiella sp. https://cjasn.asnjournals.org Clinical use of ceftriaxone: a pharmacokinetic ... - PubMed
AUC/MIC [area under the inhibitory time curve (AUIC)] was chosen as the pharmacodynamic parameter for this analysis since ceftriaxone is a time-dependent killer and high peak concentrations are not ne... https://pubmed.ncbi.nlm.nih.go Clinical use of ceftriaxone: A pharmacokinetic ... - ResearchGate
2020年7月29日 — Ceftriaxone is a third-generation cephalosporin with 83-96% protein binding. [51] The protein binding of ceftriaxone has been shown to be dose dependent with saturation of binding sites ... https://www.researchgate.net Effects of concentration-dependent plasma protein binding on ...
The kinetics of ceftriaxone, a cephalosporin, was studied in six healthy subjects who received bolus injections of 150, 500, and 1500 mg intravenously in a ... https://pubmed.ncbi.nlm.nih.go OPTIMIZING ANTIMICROBIAL PHARMACODYNAMICS: A ...
Antimicrobial killing characteristics are dependent on both the concentration of ... cephalosporins (e.g., ceftriaxone, ceftazidime, cefepime), 50%-70% fT>MIC ... https://www.sciencedirect.com Pharmacodynamics and bactericidal activity of ceftriaxone ...
Adequate concentrations of beta-lactam antibiotics in cerebrospinal fluid (CSF) are ... confirming that ceftriaxone exhibits time-dependent bactericidal activity. https://aac.asm.org Pharmacodynamics of Antimicrobial Agents: Time-Dependent ...
Interstitial fluid drug concentrations are proportional to and in rapid equilibrium with blood and, therefore, the concentration of the antibiotic correlates with bacterial ... http://www.antimicrobe.org Pharmacokinetics and Pharmacodynamics of Antibacterial ...
For example, the Vd of daptomycin and the beta-lactam ceftriaxone, which are highly ... The second group includes drugs that exhibit concentration-dependent ... https://www.ncbi.nlm.nih.gov pharmacokinetics of once-daily dosing of ceftriaxone in ...
The mean non-protein-bound or free fraction of ceftriaxone was 27% (range 1–59%). Protein binding was concentration dependent (Figure 2). In patients with normal renal function (n = 8), the mean free ... https://academic.oup.com |